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Impacts of SARS-CoV-2 Variants of Concern on Diagnostics

Aug. 26, 2021
Поделение мнений:

From the below table of Summary of phenotypic impacts of variants of concern, we acknowledge that Alpha variant has limited impact - S gene target failure and no impact on overall result from multiple target RT-PCR and no impact on Ag RDTs observed. Beta variant has no impact on RT-PCR or Ag RDTs observed. None reported to date about Gamma and Delta variants impacts on diagnostics.

 

Summary of phenotypic impacts of variants of concern —— abstracted from COVID-19 Weekly Epidemiological Update Edition 54, published 24 August 2021 by World Health Organization (WHO)

WHO label AlphaBetaGammaDelta
Transmissibility Increased transmissibility and secondary   attack rateIncreased transmissibilityIncreased transmissibilityIncreased transmissibility and secondary   attack rate.Similar transmissibility between   vaccinated and unvaccinated individuals
Disease severityIncreased risk of hospitalization,   possible increased risk of severity and mortalityNot confirmed, possible increased risk of   in-hospital mortalityNot confirmed, possible increased risk of   hospitalizationIncreased risk of hospitalization
Risk of reinfectionNeutralizing activity retained, risk of reinfection   remains similarReduction in neutralizing activity   reported; T cell response elicited by D614G virus remains effectiveModerate reduction in neutralizing   activity reportedReduction in neutralizing activity   reported
Impacts on diagnosticsLimited impact – S gene target failure   (SGTF); no impact on overall result from multiple target RTPCR, No impact on   Ag RDTs observedNo impact on RTPCR or Ag RDTs observedNone reported to dateNone reported to date

*Generalized findings as compared to previously/co-circulating variants. Based on emerging evidence, including non-peer-reviewed preprint articles and reports, all subject to ongoing investigation and revision.


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